drugset / Trial / NCT04465487

Study of REGN6569 and Cemiplimab in Adult Patients With Advanced Solid Tumor Malignancies

NCT04465487

Phase 1 Terminated 38 enrolled Regeneron Pharmaceuticals
NaSequentialOpen-labelTreatment

Summary

There are two main goals of this study: The first is to find the highest safe dose of REGN6569 when given with cemiplimab. The second is to get some initial information about how well the REGN6569 in combination with cemiplimab may help shrink certain types of cancer. The study is also looking at: * Side effects that may be experienced by people taking REGN6569 alone and with cemiplimab * How REGN6569 and cemiplimab work in the body * How much REGN6569 and cemiplimab is in your blood * To see if REGN6569 can lower the number of Treg cells in tumors * To see if REGN6569 and cemiplimab can shrink tumors when given together

Timeline

Start
2020-10-05
Primary completion
2025-02-07
Completion
2025-02-07

Drugs

EvaluationDrugModalityDoseRoute
Subject Cemiplimab Monoclonal antibody Intravenous
Subject REGN6569 Monoclonal antibody Intravenous