A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics

Phase 3 Completed 21 enrolled Adrian Vella National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

RandomizedCrossoverOpen-labelBasic science

Summary

The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.

Timeline

Start: 2022-10-17
Primary completion: 2025-09-30
Completion: 2025-12-30

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Avexitide	Peptide	—	—

Indications

No indication recorded.