drugset / Trial / NCT04467047

Safety and Feasibility of Allogenic MSC in the Treatment of COVID-19

NCT04467047

Phase 1 Unknown 10 enrolled Hospital de Clinicas de Porto Alegre
NaSingle-groupOpen-labelTreatment

Summary

Coronavirus Disease 2019 (COVID-19) is spreading worldwide and has become a public health emergency of major international concern. Currently, no specific drugs or vaccines are available. For severe cases, it was found that aberrant pathogenic T cells and inflammatory monocytes are rapidly activated and then producing a large number of cytokines and inducing an inflammatory storm. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. This study aims to investigate the safety and efficacy of intravenous infusion of mesenchymal stem cells in severe patients with COVID-19.

Timeline

Start
2020-07-25
Primary completion
2020-10-30
Completion
2020-12-30

Drugs

EvaluationDrugModalityDoseRoute
Subject mesenchymal stem cells Cell therapy 1e+06 cells/kg Intravenous

Indications