drugset / Trial / NCT04470024
Phase Ib Trial of Multivalent Autophagosome Vaccine With or Without GITR Agonist, With Anti-PD-1 Immunotherapy in HNSCC
RandomizedParallel-groupOpen-labelTreatment
Summary
This is a phase Ib study with a safety lead-in (n = 6 per arm) evaluating combinatorial DPV-001 + sequenced PD-1 blockade, with or without GITR agonist, in recurrent or metastatic HNSCC.
Timeline
- Start
- 2021-08-05
- Primary completion
- 2027-12-31
- Completion
- 2028-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | DPV-001 | Vaccine | — | — |
| Subject | RAGIFILIMAB | Monoclonal antibody | — | — |
| Subject | Retifanlimab | Monoclonal antibody | — | — |