Effects of Baclofen on Presynaptic Inhibition in Humans

Summary

This study examines the role of the GABA-B receptor in long-lasting presynaptic inhibition of primary afferents in human participants. Participants will come in for two visits, receiving baclofen (a GABA-B receptor agonist) on one visit and a placebo during the other. Electro-physiological measures will be use during both visit to asses presynaptic inhibition.

Timeline

Start

2020-01-10

Primary completion

2022-03-17

Completion

2022-03-17

Drugs

Indications