Tfh Dysfunction in HIV and Aging

Phase 4 Active not recruiting 400 enrolled University of Miami

Non-randomizedSequentialOpen-labelBasic science

Summary

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people to understand how aging and HIV infection affect the immune responses (body defenses against infection) to the flu vaccine.

Timeline

Start: 2020-10-30
Primary completion: 2027-04-30
Completion: 2027-12-30

Publications

Kupritz J, Davis S, Liu T, Singh P, Diaz-Pachon DA, Rodriguez A, Boyd SD, Pahwa R, Pallikkuth S, Pahwa SG. High-dose influenza vaccine augments serological and cellular immunity of older people with HIV. JCI Insight. 2026 Mar 5;11(8):e199232. doi: 10.1172/jci.insight.199232. eCollection 2026 Apr 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	High dose influenza vaccination	Vaccine	0.7 ml	Intramuscular
Subject	Influenza Virus Vaccine	Vaccine	0.5 ml	Intramuscular

Tfh Dysfunction in HIV and Aging

Summary

Timeline

Publications

Drugs

Indications