A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV

Summary

Many people living with HIV (PLWH) smoke. Smoking in these individuals is often undertreated. This study plans to assess the ability of various clinical pathways involving tobacco treatment medications and contingency management (paying smokers for not smoking) to improve smoking cessation in a group of PLWH.

Timeline

Start

2020-07-27

Primary completion

2024-10-24

Completion

2025-10-24

Publications

• Edelman EJ, Deng Y, Dziura J, Nahum-Shani I, Weiss JM, Aoun-Barakat L, Bold KW, Harsono D, Mistler C, Payne E, Aiudi S, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL. Clinical Pharmacists, Medications, and Contingency Management for Targeting Smoking in HIV Clinics: A Randomized Clinical Trial. JAMA Netw Open. 2026 Feb 2;9(2):e2560593. doi: 10.1001/jamanetworkopen.2025.60593.
• Edelman EJ, Dziura J, Deng Y, Bold KW, Murphy SM, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL. A SMARTTT approach to Treating Tobacco use disorder in persons with HIV (SMARTTT): Rationale and design for a hybrid type 1 effectiveness-implementation study. Contemp Clin Trials. 2021 Nov;110:106379. doi: 10.1016/j.cct.2021.106379. Epub 2021 Mar 29.

Drugs

Indications