Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D (RHYTHM)

Summary

The purpose of this study was to generate effectiveness data of Angiotensin receptor neprilysin inhibitor (ARNI), in the Chinese Heart failure with reduced ejection fraction (HFrEF) patients with implantable cardioverted defibrillator (ICD) or Cardiac resynchronization therapy-defibrillator (CRT-D).

Timeline

Start

2020-11-11

Primary completion

2023-06-08

Completion

2023-06-08

Outcome

Missed primary endpoint

Stopped: “Company decision”

registry analysis (other test); ACEI/ARB vs ARNI; p >0.9999; McNemar NCT04491136 ↗

registry analysis (other test); ACEI/ARB vs ARNI; p = 0.7905; McNemar NCT04491136 ↗

registry analysis (other test); ACEI/ARB vs ARNI; p = 0.6250; McNemar NCT04491136 ↗

registry analysis (other test); ACEI/ARB vs ARNI; p = 0.0654; McNemar NCT04491136 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sacubitril/valsartan	Unknown	200 mg	Oral

Indications