Trochanteric Femur Fracture Operated With Dynamic Hip Screw System (DHS) Augmented With a Biphasic Apatite Sulphate Combined With Systemic or Local Bisphosphonate

Unknown 20 enrolled Lithuanian University of Health Sciences Lund University Hospital · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to study the process of bone regeneration around a metal device in the femoral neck canal using a synthetic bone substitute Cerament bone void filler (BVF) and bisphosphonate (Zometa) locally or systemically that affects bone metabolism. Furthermore, fracture healing and implant migration will be investigated.

Timeline

Start: 2021-06-01
Primary completion: 2024-06
Completion: 2024-12

Publications

Results Raina DB, Markeviciute V, Stravinskas M, Kok J, Jacobson I, Liu Y, Sezgin EA, Isaksson H, Zwingenberger S, Tagil M, Tarasevicius S, Lidgren L. A New Augmentation Method for Improved Screw Fixation in Fragile Bone. Front Bioeng Biotechnol. 2022 Mar 2;10:816250. doi: 10.3389/fbioe.2022.816250. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Zoledronic acid	Other / unclassified	1 mg	Intravenous
Subject	Zoledronic acid	Other / unclassified	2 mg	Intravenous
Subject	Zoledronic acid	Other / unclassified	4 mg	Intravenous

Indications

No indication recorded.