drugset / Trial / NCT04515979

Vactosertib in Combination with Pembrolizumab for PD-L1 Positive Non-small Cell Lung Cancer (NSCLC) Subjects

NCT04515979 ↗

Phase 2 Terminated 11 enrolled MedPacto, Inc.
NaSingle-groupOpen-labelTreatment

Summary

This is Phase 2, open label, multi-center study to assess safety and efficacy of vactosertib in combination with pembrolizumab as 1st line treatment for subjects with advanced or metastatic, PD-L1 positive, non-small cell lung cancer (NSCLC) who have not previously received systemic therapy for advanced disease and in whom EGFR, ALK, BRAF, ROS1-directed therapy is not indicated.

Timeline

Start
2020-12-17
Primary completion
2024-08-05
Completion
2024-08-05

Outcome

Outcome not reported

Stopped (Business): “This is because Medpacto decided to modify its development strategy as the business and development environment changed.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous
Subject Vactosertib Small molecule 300 mg Oral