drugset / Trial / NCT04520178
Effects of 5HTP on the Injured Human Spinal Cord
RandomizedCrossoverDouble-blindBasic science
Summary
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
Timeline
- Start
- 2020-07-01
- Primary completion
- 2026-06-30
- Completion
- 2026-12-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | 5-Hydroxytryptophan | Other / unclassified | 50 mg | — |
| Comparator | 5-Hydroxytryptophan | Other / unclassified | 100 mg | — |
| Comparator | Carbidopa | Unknown | 50 mg | — |