Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia

Summary

The purpose of this study is to investigate whether a blood pressure medication, spironolactone, can be tolerated by older African American adults that have memory and thinking problems, also called mild cognitive impairment (MCI). This study will also investigate the effect of spironolactone on memory and thinking abilities as measured by performance on cognitive tests, which are tests that measure memory and thinking skills. Participants will take spironolactone or a placebo for one year and will have 4 to 5 study visits during the study period.

Timeline

Start

2022-09-06

Primary completion

2025-09-23

Completion

2025-09-23

Drugs

Indications