drugset / Trial / NCT04528095
SMART Design to Compare Antipsychotic Treatments in Treatment-Resistant Schizophrenia
RandomizedSequentialSingle-blindTreatment
Summary
The project intends to take treatment-resistant schizophrenia as the research object and uses sequential multiple assignment randomized trial(SMART) design to define the treatment recommendations of different drug regimen for treatment resistant schizophrenia and to determine the physical enhancement regimen for clozapine-resistant schizophrenia and to explore targeted regulation scheme for ultra-resistant schizophrenia.
Timeline
- Start
- 2020-12
- Primary completion
- 2022-12
- Completion
- 2022-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amisulpride | Small molecule | 200 mg | — |
| Subject | Amisulpride | Small molecule | 800 mg | — |
| Subject | Clozapine | Other / unclassified | 400 mg | — |
| Subject | Clozapine | Other / unclassified | 600 mg | — |
| Subject | Gingke biloba | Unknown | 120 mg | — |
| Subject | Gingke biloba | Unknown | 360 mg | — |