Therapeutic Effect of Tacrosolv in Patients With Allergic Rhinoconjunctivitis

Summary

Allergic conjunctivitis is one of the most common comorbidities of allergic diseases, especially of allergic rhinitis. Rhinoconjunctivitis is an allergic condition of the nasal mucosa and the eyes. Conjunctivitis is triggered by hypersensitivity to certain pollens and other airborne allergens and causes several symptoms such as reddened eyes, itchy eyes and can cause watery eyes and a scratchy feeling in the eye. Tacrolimus is a well-known immunosuppressiv active substance which is hardly soluble in water. Within Tacrosolv, Tacrolimus is completely dissolves in aqueous solution. The effectiveness of Tacrosolv will be tested for treatment of allergic conjunctivitis. Allergic subjects will be treated with aqueous formulation of tacrolimus 'Tacrosolv 50 micrograms per milliliter, eye drops' for 8 days. On day 1 and day 8 allergic patients will be challenged with grass pollen for a period of 4 hours and subjective allergic symptoms will be assessed.

Timeline

Start

2020-08-04

Primary completion

2021-05-27

Completion

2021-05-27

Publications

• Sladek S, Unger-Manhart N, Siegl C, Dellago H, Zieglmayer PU, Lemell P, Savli M, Zieglmayer R, Geitzenauer W, Langauer M, Prieschl-Grassauer E. Alleviation of Allergic Rhinoconjunctivitis Symptoms in Participants Treated with a 0.005% Tacrolimus Eye-Drop Solution. Clin Ophthalmol. 2024 Oct 5;18:2797-2811. doi: 10.2147/OPTH.S476163. eCollection 2024.

Drugs

Indications