drugset / Trial / NCT04539951
Pragmatic Trial of Obsessive-compulsive Disorder
Phase 2
Recruiting
1600 enrolled
Shanghai Mental Health Center
First Affiliated Hospital of Jinan University · collabFirst Affiliated Hospital of Kunming Medical University · collabGeneral Hospital of Ningxia Medical University · collabGuizhou Provincial People's Hospital · collabNanjing Medical University · collabSeventh People's Hospital of Hangzhou · collabSuzhou Psychiatric Hospital · collabThe First Affiliated Hospital of Nanchang University · collabThe Second Affiliated Hospital of Xinxiang Medical University · collabThe first specialized hospital of harbin · collabWest China Hospital · collabWuhan Mental Health Centre · collab
RandomizedSequentialSingle-blindTreatment
Summary
This study includes a sequenced clinical trial in order to assess the efficacy of several switching or augment strategies when initial treatment is ineffective，and to provide strong evidence for clinical practice and international guidelines for Obsessive-Compulsive Disorder treatments.
Timeline
- Start
- 2020-09-22
- Primary completion
- 2027-06-30
- Completion
- 2028-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aripiprazole | Other / unclassified | 20 mg | — |
| Comparator | Fluvoxamine | Unknown | 300 mg | — |
| Comparator | Memantine | Unknown | 20 mg | — |
| Comparator | Sertraline | Small molecule | 200 mg | — |
| Comparator | Sertraline | Small molecule | 300 mg | — |
| Comparator | Venlafaxine | Small molecule | 300 mg | — |