drugset / Trial / NCT04545892
Capsaicin for Cerebral Perfusion Augmentation.
Phase 1
Completed
30 enrolled
Juan Manuel Marquez Romero
Centenario Hospital Miguel Hidalgo · collabUniversidad de Guanajuato · collab
NaSingle-groupOpen-labelOther
Summary
To determine the safety and effect of crescent doses of capsaicin upon serial transcranial Doppler (TCD) markers of cerebral blood flow (CBF). Methods We performed serial TCD testing in 30 healthy volunteers divided into five equal groups. Capsaicin doses ranged from 33 to 165 μMol. We recorded peak systolic and end-diastolic velocities in the middle cerebral artery (MCA), arterial pressure, and perceived pungency (PP) in five minutes intervals up to 20 minutes. We then calculated the mean velocity (MV), the pulsatility index (PI), and the CBF index.
Timeline
- Start
- 2019-12-01
- Primary completion
- 2020-07-31
- Completion
- 2020-07-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Capsaicin | Small molecule | 33 unknown | Oral |
| Subject | Capsaicin | Small molecule | 66 unknown | Oral |
| Subject | Capsaicin | Small molecule | 99 unknown | Oral |
| Subject | Capsaicin | Small molecule | 132 unknown | Oral |
| Subject | Capsaicin | Small molecule | 165 unknown | Oral |