drugset / Trial / NCT04545944
Evaluation of Effect of Vonoprazan on Midazolam Pharmacokinetics in Healthy Participants
NaSingle-groupOpen-labelTreatment
Summary
To determine the time-dependent inhibition potential of repeated doses of oral vonoprazan on the pharmacokinetics (PK) of a single oral dose of midazolam, a sensitive cytochrome P450 3A4 (CYP3A4) substrate, in healthy participants.
Timeline
- Start
- 2020-09-15
- Primary completion
- 2020-11-13
- Completion
- 2020-11-25
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Midazolam | Small molecule | 2 mg | Oral |
| Subject | Vonoprazan | Other / unclassified | 20 mg | Oral |
Indications
No indication recorded.