drugset / Trial / NCT04554888
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor
RandomizedCrossoverSingle-blindBasic science
Summary
In this experiment the investigators would like to assess if papain induces an itch sensation comparable to the itch sensation induced by cowhage and to confirm that the mechanism of action of papain follows the non-histaminergic pathway.
Timeline
- Start
- 2022-03-01
- Primary completion
- 2022-05-31
- Completion
- 2022-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Doxepin | Unknown | 1.2 g | Topical |
| Subject | Histamine | Small molecule | — | Other |
| Subject | Papain | Protein / enzyme biologic | — | Other |
Indications
No indication recorded.