Effect of Ketanserin After LSD Administration

Phase 1 Completed 24 enrolled University Hospital, Basel, Switzerland

RandomizedCrossoverTriple-blindBasic science

Summary

LSD (lysergic acid diethylamide) is a serotonergic (5-HT) hallucinogen widely used for recreational and/or ethnomedical purposes. LSD is thought to induce its prototypical psychedelic effects primarily via stimulation of the 5-HT2A receptor. This study investigates whether an LSD experience can be attenuated and shortened using 5-HT2A receptor antagonist ketanserin administration after LSD once the psychedelic effects have established.

Timeline

Start: 2020-10-16
Primary completion: 2021-08-28
Completion: 2021-09-29

Publications

Becker AM, Klaiber A, Holze F, Istampoulouoglou I, Duthaler U, Varghese N, Eckert A, Liechti ME. Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants. Int J Neuropsychopharmacol. 2023 Feb 14;26(2):97-106. doi: 10.1093/ijnp/pyac075.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketanserin	Small molecule	40 mg	Oral
Subject	Lysergic Acid Diethylamide	Other / unclassified	100 ug	Oral

Indications

No indication recorded.