The Effects of Salbutamol on Mannitol Induced Cough Responses in Healthy Controls

Summary

The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke coughing healthy controls with no evidence of bronchoconstriction (PC20\>16mg/ml or mannitol PD15 \> 635 mg, or \< 10% incremental fall in FEV1 between consecutive mannitol doses) and if salbutamol can affect this. This is a double-blind, placebo-controlled analysis in healthy controls assessing the effects of salbutamol on mannitol induced cough.

Timeline

Start

2020-11-30

Primary completion

2021-12-16

Completion

2021-12-16

Drugs

Indications

No indication recorded.