Methotrexate in Erosive Inflammatory Hand Osteoarthritis

Phase 4 Active not recruiting 163 enrolled Diakonhjemmet Hospital Oslo University Hospital · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

A placebo-controlled randomized controlled trial exploring the effect of methotrexate on pain, function and structural outcomes in erosive inflammatory hand osteoarthritis.

Timeline

Start: 2021-08-12
Primary completion: 2026-12
Completion: 2026-12

Publications

Mathiessen A, Gaundal L, Sexton J, Sjolie D, Steen Pettersen P, Slatkowsky-Christensen B, Haugen IK. Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis. Osteoarthr Cartil Open. 2024 Dec 15;7(1):100558. doi: 10.1016/j.ocarto.2024.100558. eCollection 2025 Mar.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Methotrexate	Small molecule	20 mg	Oral
Comparator	folic acid	Other / unclassified	1 mg	—

Methotrexate in Erosive Inflammatory Hand Osteoarthritis

Summary

Timeline

Publications

Drugs

Indications