drugset

drugset / Trial / NCT04585542

Comparison of Potassium Binders in the ER

NCT04585542 ↗

Phase 4 Terminated 37 enrolled University of California, Irvine

RandomizedParallel-groupDouble-blindTreatment

Summary

Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in hospital patients with acute hyperkalemia.

Timeline

Start: 2020-10-20
Primary completion: 2025-01-31
Completion: 2025-01-31

Publications

Background Leon SJ, Harasemiw O, Tangri N. New therapies for hyperkalemia. Curr Opin Nephrol Hypertens. 2019 May;28(3):238-244. doi: 10.1097/MNH.0000000000000500.
Background Betts KA, Woolley JM, Mu F, Xiang C, Tang W, Wu EQ. The Cost of Hyperkalemia in the United States. Kidney Int Rep. 2017 Nov 14;3(2):385-393. doi: 10.1016/j.ekir.2017.11.003. eCollection 2018 Mar.
Canas AE, Troutt HR, Jiang L, Tonthat S, Darwish O, Ferrey A, Lotfipour S, Kalantar-Zadeh K, Hanna R, Lau WL. A randomized study to compare oral potassium binders in the treatment of acute hyperkalemia. BMC Nephrol. 2023 Apr 5;24(1):89. doi: 10.1186/s12882-023-03145-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Patiromer	Other / unclassified	25.2 g	Oral
Subject	Sodium Zirconium Cyclosilicate	Other / unclassified	15 g	Oral
Subject	polyethylene glycol	Other / unclassified	17 g	Oral
Subject	sodium polystyrene sulfonate	Other / unclassified	30 g	Oral

Indications

No indication recorded.