Colchicine as Treatment for People With Hand Osteoarthritis

Summary

The study aims to compare oral colchicine 0.5 mg administered two times daily for 12 weeks with placebo as a treatment of hand OA symptoms.

Timeline

Start

2021-01-15

Primary completion

2022-08-03

Completion

2022-08-03

Outcome

Missed primary endpoint

paper between-group difference (colchicine vs placebo) of -0·4 mm (95% CI -7·6 to 6·7; p=0·90). PMID 38251589 ↗

Publications

• Dossing A, Henriksen M, Ellegaard K, Nielsen SM, Stamp LK, Muller FC, Kloppenburg M, Haugen IK, McCarthy GM, Conaghan PG, Ulff-Moller Dahl L, Terslev L, Altman RD, Becce F, Ginnerup-Nielsen E, Jensen L, Boesen M, Christensen R, Dal U, Bliddal H. Colchicine twice a day for hand osteoarthritis (COLOR): a double-blind, randomised, placebo-controlled trial. Lancet Rheumatol. 2023 May;5(5):e254-e262. doi: 10.1016/S2665-9913(23)00065-6. Epub 2023 Apr 4.

Drugs

Indications