MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA

Summary

In this three-year proposal, we will explore the MRI-visible EPVS in CAA and investigate its pathophysiology using animal models. Our specific aims include: (1) Establish the relationship of MRI-visible enlarged perivascular space and CAA, (2) Determine whether vascular amyloid clearance in CAA is associated with lymphatic drainage system, (3) Establish longitudinal data for MRI-visible enlarged perivascular space and cerebral amyloid angiopathy progression.

Timeline

Start

2020-10-08

Primary completion

2023-07-31

Completion

2023-07-31

Drugs

Indications