Levels of Matrix Metalloproteinase-8 After Intrapocket Treatment in Moderate Periodontitis Patients.

Summary

Using local delivery drugs as adjunctive to scaling and root planing and evaluating gingival crevicular fluid (GCF) biological molecular markers (MMP-8).

Timeline

Start

2020-01-13

Primary completion

2020-08-31

Completion

2020-10-14

Publications

• Background Bascones-Martinez A, Munoz-Corcuera M, Noronha S, Mota P, Bascones-Ilundain C, Campo-Trapero J. Host defence mechanisms against bacterial aggression in periodontal disease: Basic mechanisms. Med Oral Patol Oral Cir Bucal. 2009 Dec 1;14(12):e680-5. doi: 10.4317/medoral.14.e680.
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• Background Hernández-Ríos P, Hernández M, Garrido M, Tervahartiala T, Leppilahti J, Kuula H, et al. Oral fluid matrix metalloproteinase (MMP)-8 as a diagnostic tool in chronic periodontitis. Dove Press. 2016; 2016(30):11-18.
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• Background Kinney JS, Morelli T, Oh M, Braun TM, Ramseier CA, Sugai JV, Giannobile WV. Crevicular fluid biomarkers and periodontal disease progression. J Clin Periodontol. 2014 Feb;41(2):113-120. doi: 10.1111/jcpe.12194. Epub 2013 Dec 12.
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• Background Grover S, Tewari S, Sharma RK, Singh G, Yadav A, Naula SC. Effect of Subgingivally Delivered 10% Emblica officinalis Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis - A Randomized Placebo-controlled Clinical Trial. Phytother Res. 2016 Jun;30(6):956-62. doi: 10.1002/ptr.5600. Epub 2016 Feb 24.
• Background Phogat M, Rana T, Prasad N, Baiju CS. Comparative evaluation of subgingivally delivered xanthan-based chlorhexidine gel and herbal extract gel in the treatment of chronic periodontitis. J Indian Soc Periodontol. 2014 Mar;18(2):172-7. doi: 10.4103/0972-124X.131319.
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• Background Ghosh G. Traditional use of plants against leprosy in India: a review of the recent literature. J Innov Pharm Biol Sci. 2017;4(4): 55-64.
• Background Silva-Neto RP, Peres MF, Valenca MM. Odorant substances that trigger headaches in migraine patients. Cephalalgia. 2014 Jan;34(1):14-21. doi: 10.1177/0333102413495969. Epub 2013 Jul 5.
• Background Arrey Tarkang P, Franzoi KD, Lee S, Lee E, Vivarelli D, Freitas-Junior L, Liuzzi M, Nole T, Ayong LS, Agbor GA, Okalebo FA, Guantai AN. In vitro antiplasmodial activities and synergistic combinations of differential solvent extracts of the polyherbal product, Nefang. Biomed Res Int. 2014;2014:835013. doi: 10.1155/2014/835013. Epub 2014 Apr 27.
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• Background Figueirinha A, Francisco V, Costa G, Liberal J, Lopes M, García-Rodríguez C, et al. Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass. J Funct Foods. 2014;10(2):436-443
• Background Francisco V, Costa G, Figueirinha A, Marques C, Pereira P, Miguel Neves B, Celeste Lopes M, Garcia-Rodriguez C, Teresa Cruz M, Teresa Batista M. Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-kappaB pathway inhibition: contribution of chlorogenic acid. J Ethnopharmacol. 2013 Jun 21;148(1):126-34. doi: 10.1016/j.jep.2013.03.077. Epub 2013 Apr 10.
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• Background Anand M, Goyal R, Bhat S, Kamath S, Aggarwal M, Bhandarkar M, et al. A novel anti-oxidant lemon grass oil mouth wash-a clinical trial. J Exp Biol Sci. 2011;2(3): 59-64.
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• Background Prabahar C, Nivetha R. Evaluation of efficacy of lemongrass gel as a local drug delivery with chlorhexidine gel in chronic periodontitis -a comparative study. Int J Adv Res. 2017;6(9): 6017-6020.
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• Background Gul SS, Griffiths GS, Stafford GP, Al-Zubidi MI, Rawlinson A, Douglas CWI. Investigation of a Novel Predictive Biomarker Profile for the Outcome of Periodontal Treatment. J Periodontol. 2017 Nov;88(11):1135-1144. doi: 10.1902/jop.2017.170187. Epub 2017 Jul 3.
• Background Nedzi-Gora M, Gorska R, Kostrzewa-Janicka J, Kowalski J. Concentration of MMP-8 and IL-1beta in gingival crevicular fluid in patients with chronic and aggressive periodontitis. Cent Eur J Immunol. 2017;42(4):342-346. doi: 10.5114/ceji.2017.72824. Epub 2017 Dec 30.
• Background Buduneli N, Kinane DF. Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J Clin Periodontol. 2011 Mar;38 Suppl 11:85-105. doi: 10.1111/j.1600-051X.2010.01670.x.
• Background Sorsa T, Tjaderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 2004 Nov;10(6):311-8. doi: 10.1111/j.1601-0825.2004.01038.x.
• Background Reinhardt RA, Stoner JA, Golub LM, Lee HM, Nummikoski PV, Sorsa T, Payne JB. Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis. J Periodontol. 2010 Feb;81(2):251-9. doi: 10.1902/jop.2009.090374.
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• Background Guentsch A, Kramesberger M, Sroka A, Pfister W, Potempa J, Eick S. Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis. J Periodontol. 2011 Jul;82(7):1051-60. doi: 10.1902/jop.2011.100565. Epub 2011 Jan 14.
• Background Kinane DF, Darby IB, Said S, Luoto H, Sorsa T, Tikanoja S, Mantyla P. Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance. J Periodontal Res. 2003 Aug;38(4):400-4. doi: 10.1034/j.1600-0765.2003.00663.x.
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Drugs

Indications