drugset / Trial / NCT04606771

A Study Comparing Savolitinib Plus Osimertinib vs Savolitinib Plus Placebo in Patients With EGFRm+ and MET Amplified Advanced NSCLC

NCT04606771

Phase 2 Active not recruiting 30 enrolled AstraZeneca
RandomizedParallel-groupDouble-blindTreatment

Summary

This study will compare the activity of the combination of savolitinib and osimertinib against the combination of savolitinib with placebo to osimertinib in patients with Epidermal Growth Factor Receptor Mutation Positive and MET amplified, locally advanced or metastatic non-small cell lung cancer who have progressed following treatment with osimertinib.

Timeline

Start
2020-09-28
Primary completion
2022-12-21
Completion
2026-03-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Osimertinib Small molecule 80 mg Oral
Subject Savolitinib Small molecule 300 mg Oral