drugset / Trial / NCT04608344
Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy Participants
RandomizedCrossoverOpen-labelBasic science
Summary
The primary objective of this study is to evaluate the effect of filgotinib on a mixed organic anion transporting polypeptide/cytochrome P450 3A (OATP/CYP3A), OATP/ breast cancer resistance protein (BCRP), and OATP substrates using phenotypic probes.
Timeline
- Start
- 2020-11-04
- Primary completion
- 2021-01-13
- Completion
- 2021-01-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atorvastatin | Small molecule | 40 mg | Oral |
| Subject | Filgotinib | Small molecule | 200 mg | Oral |
| Subject | Pravastatin | Small molecule | 40 mg | Oral |
| Subject | Rosuvastatin | Small molecule | 10 mg | Oral |