Optimal Dosing of Preoperative Gabapentin for Prevention of Postoperative Nausea and Vomiting
Summary
Overall incidence of postoperative nausea and vomiting (PONV) after general anesthesia is 40-90 % . gabapentin has been incorporated into "fast-track" packages and improved recovery during surgery protocols to avoid unintended side effects associated with opioid alternatives. Interestingly, gabapentin has also been noted to reduce the effects of chemotherapy-induced nausea, effective in treatment of gravidarum hyperemesis, and postdural puncture emesis. Different dosing regimens were tested.The goal of the study is to determine the most effective dose of oral gabapentin given 1 hour prior to surgery on the occurrence and severity of PONV and drug side effects in the first 24 hours postoperatively to find the most effective dose of gabapentin with the least side effects.
Timeline
- Start
- 2020-09-15
- Primary completion
- 2021-01-20
- Completion
- 2021-02-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Gabapentin | Small molecule | 300 mg | Oral |
| Comparator | Gabapentin | Small molecule | 600 mg | Oral |
| Comparator | Gabapentin | Small molecule | 900 mg | Oral |
Indications
No indication recorded.