Nasal Septum Perforation Treatment Using Tissue Engineered Cartilage Graft

Phase 1 Completed 5 enrolled University Hospital, Basel, Switzerland Dr Josef Vavrina, HNO Seepraxen, CH-8810 Horgen, Zurich · collab

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to investigate the safety and feasibility of implanting an engineered cartilage tissue in an interposition graft with a temporoparietal fascia (TPF) flap to repair medium size septal perforation. The engineered cartilage graft is obtained by culturing expanded autologous nasal chondrocytes within a collagen type I/III membrane. In addition, first data on efficacy will be collected.

Timeline

Start: 2021-04-09
Primary completion: 2023-04-24
Completion: 2023-04-24

Publications

Kaiser B, Miot S, Wixmerten A, Pullig O, Eyrich M, Fulco I, Vavrina J, Schaefer DJ, Martin I, Barbero A, Haug MD. Engineered autologous nasal cartilage for repair of nasal septal perforations: a case series. Int J Surg. 2024 Oct 1;110(10):6573-6580. doi: 10.1097/JS9.0000000000001843.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N-TEC	Unknown	—	Other

Indications

No indication recorded.