Pharmacokinetic Interaction Between Tegoprazan and NSAIDs After Multiple Oral Dosing in Healthy Male Volunteers

Phase 1 Completed 60 enrolled HK inno.N Corporation

RandomizedCrossoverOpen-labelTreatment

Summary

This study aims to evaluate the pharmacokinetic (PK) interaction between tegoprazan and non-steroidal anti-inflammatory drugs (NSAIDs) after given each alone and in their combination in healthy male adults.

Timeline

Start: 2020-06-06
Primary completion: 2020-07-26
Completion: 2020-07-29

Publications

Moon SJ, Shin N, Kang M, Kim B, Kim MG. Pharmacokinetic Interactions Between Tegoprazan and Naproxen, Aceclofenac, and Celecoxib in Healthy Korean Male Subjects. Clin Ther. 2022 Jul;44(7):930-944.e1. doi: 10.1016/j.clinthera.2022.06.002. Epub 2022 Jul 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Aceclofenac	Small molecule	100 mg	Oral
Comparator	Celecoxib	Other / unclassified	200 mg	Oral
Comparator	Naproxen	Small molecule	500 mg	Oral
Comparator	Tegoprazan	Other / unclassified	50 mg	Oral

Indications

No indication recorded.