drugset / Trial / NCT04643132
S-ketamine Prevents Postoperative Pain and Cognitive Dysfunction After Tibial Fracture
RandomizedParallel-groupDouble-blindPrevention
Summary
Purpose: To explore effects of S-ketamine on postoperative pain and cognitive dysfunction after tibial fracture and orthopedic surgery. To evaluate and examine the incidence of adverse effects with the purpose of selecting the optimum dose.
Timeline
- Start
- 2020-12-15
- Primary completion
- 2021-11-15
- Completion
- 2021-12-15
Publications
- Background Zhang L, Terrando N, Xu ZZ, Bang S, Jordt SE, Maixner W, Serhan CN, Ji RR. Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice. Front Pharmacol. 2018 May 1;9:412. doi: 10.3389/fphar.2018.00412. eCollection 2018.
- Background Cui W, Li Y, Wang Z, Song C, Yu Y, Wang G, Li J, Wang C, Zhang L. Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity through netrin-1 in postoperative pain after orthopedic surgery for tibial fracture in mice. Pain. 2021 Jan;162(1):124-134. doi: 10.1097/j.pain.0000000000002021.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Esketamine | Other / unclassified | 0.2 mg/kg | Intravenous |
| Comparator | Esketamine | Other / unclassified | 0.4 mg/kg | Intravenous |
Indications
No indication recorded.