hCG Priming in Women With Low Ovarian Reserve

Summary

The aim of this trial is to examine the possible effects of hCG administration for eight weeks prior to IVF/ICSI in women with low ovarian reserve. Primary outcome is the proportion of the antral follicle count that reach the pre-ovulatory stage.

Timeline

Start

2020-12-27

Primary completion

2021-08-31

Completion

2021-08-31

Outcome

Missed primary endpoint

paper did not increase after 8 weeks of hCG priming (P = 0.8). PMID 36721920 ↗

Publications

• Friis Wang N, Bogstad JW, Petersen MR, Pinborg A, Yding Andersen C, Lossl K. Androgen and inhibin B levels during ovarian stimulation before and after 8 weeks of low-dose hCG priming in women with low ovarian reserve. Hum Reprod. 2023 Sep 5;38(9):1807-1815. doi: 10.1093/humrep/dead134.
• Friis Wang N, Bogstad JW, Pors SE, Petersen MR, Pinborg A, Yding Andersen C, Lossl K. Eight weeks of androgen priming by daily low-dose hCG injections before ICSI treatment in women with low ovarian reserve. Hum Reprod. 2023 Apr 3;38(4):716-725. doi: 10.1093/humrep/dead012.

Drugs

Indications