The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

Summary

The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.

Timeline

Start

2026-09-01

Primary completion

2027-03-01

Completion

2027-03-01

Drugs

Indications

No indication recorded.