Influence of Fampridine on Working Memory in Healthy Young Subjects

Phase 2 Completed 44 enrolled University of Basel Clinical Trial Unit, University Hospital Basel, Switzerland · collab University Hospital, Basel, Switzerland · collab

RandomizedCrossoverQuadruple-blindBasic science

Summary

Proof of concept study on the acute effects on working memory of 10 mg fampridine SR as well as the effects after repeated administration of 10 mg twice daily (3.5 days). The hypothesis ist that fampridine improves working memory performance.

Timeline

Start: 2021-11-01
Primary completion: 2023-01-26
Completion: 2023-01-26

Outcome

Missed primary endpoint

paper Independently of baseline cognitive performance, no significant main effect was observed (Wilcoxon P = 0.87, r = 0.026). PMID 39516710 ↗

Publications

Papassotiropoulos A, Freytag V, Schicktanz N, Gerhards C, Aerni A, Faludi T, Amini E, Muggler E, Harings-Kaim A, Schlitt T, de Quervain DJ. The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach. Mol Psychiatry. 2025 May;30(5):2085-2094. doi: 10.1038/s41380-024-02820-1. Epub 2024 Nov 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dalfampridine	Unknown	10 mg	Oral

Indications

No indication recorded.