drugset / Trial / NCT04657224

A Study of JNJ-64264681 and JNJ-67856633 in Participants With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia

NCT04657224

Phase 1 Completed 75 enrolled Janssen Research & Development, LLC
Non-randomizedSequentialOpen-labelTreatment

Summary

The primary purpose of this study is to determine: the recommended Phase 2 doses (RP2Ds) of JNJ-64264681 and JNJ 67856633 when administered together in participants with B cell non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) (Part A - Dose Escalation); and the safety of the RP2Ds for this combination in different histologies/participant populations (Part B - Cohort Expansion).

Timeline

Start
2021-02-25
Primary completion
2025-01-16
Completion
2025-01-16

Drugs

EvaluationDrugModalityDoseRoute
Subject JNJ-64264681 Small molecule Oral
Subject SAFIMALTIB Small molecule Oral