drugset / Trial / NCT04665830

PCSK 9 Inhibition as Secondary Prevention in Renal Transplant Patients

NCT04665830

Phase 3 Completed 200 enrolled Hamid Al-Essa Organ Transplant Center
RandomizedParallel-groupOpen-labelPrevention

Summary

From this randomized controlled study, we aim to: A.Do do cardiovascular risk stratification of renal transplant recipients who are followed up in Hamed Al-Essa organ transplant center of Kuwait. B. To compare the effectiveness of a PCSK9 inhibitor plus maximum tolerated statin therapy vs. maximum tolerated statin therapy alone in the reduction of major cardiovascular events among renal transplant recipients with cardiovascular disease. C. To compare the effectiveness of a PCSK9 inhibitor plus maximum tolerated statin therapy vs. maximum tolerated statin therapy alone in terms of LDL-C-lowering, muscle symptoms, and quality of life. D. To compare patient adherence to the different treatment protocols.

Timeline

Start
2018-05-01
Primary completion
2020-05-01
Completion
2020-05-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Evolocumab Monoclonal antibody 140 mg Subcutaneous

Indications

No indication recorded.