Precision Dosing of Vancomycin in Critically Ill Children

Phase 4 Completed 314 enrolled University Hospital, Ghent Belgium Health Care Knowledge Centre · collab University Ghent · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The overall objective of this project is to investigate the large-scale utility of MIPD of vancomycin at point-of-care in ICU children. This evaluation includes a comparison with the more standard approach on Clinical and patient-oriented measures.

Timeline

Start: 2020-12-28
Primary completion: 2023-12-14
Completion: 2024-10-30

Publications

De Cock PA, Colman R, Smits A, Piersigilli F, Renard M, Van Damme A, Clarysse A, Dhont E, Vanhaesebrouck S, Bordon V, Boland L, De Wilde B, Amza A, Vanlanduyt L, Nguyen TVA, Cools F, van der Werff Ten Bosch J, Vens D, Derriks F, Houtekie L, Mauel R, Van der Linden D, Schelstraete P; BENEFICIAL study group. Bedside model-informed precision dosing of vancomycin in severely ill neonates and children in Belgium (the BENEFICIAL trial): a multicentre, randomised controlled trial. Lancet Child Adolesc Health. 2026 Jun;10(6):406-417. doi: 10.1016/S2352-4642(25)00385-2. Epub 2026 Apr 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vancomycin	Other / unclassified	—	Intravenous

Indications

No indication recorded.