Safety and Efficacy Study of Clevidipine Butyrate Injection in Hypertensive Emergencies

Summary

The purpose of this study was to determine the efficacy and safety of clevidipine for treating Hypertensive emergencies（defined as systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>120 mmHg, accompanied by acute organ damage）.

Timeline

Start

2020-07-27

Primary completion

2021-08

Completion

2021-12

Publications

• Lv Q, Chen C, Lin L, Zhao X, Chen J, Liang Z, Chai Y, Du B, Sun L, Chen X, Liu M, Zhang X, Cao Z, Zhang H, Chen D, Wang Z, Zhong Y, Zhu J, Gao F, Wang X, Zhang G, Li L, Ma J, Zhao M, Ouyang Y, Guo S, Wang H, Yang P, He R, Zhao Z, Sun L, Wu L, Wu Y, Liu X, Xu T, Li N, Zhu T, Ma C. Efficacy and safety of clevidipine emulsion injection compared with nicardipine in patients with hypertensive emergencies: a randomized, single-blind, positive-parallel-controlled, phase III clinical trial. J Hypertens. 2026 Jan 1;44(1):204-210. doi: 10.1097/HJH.0000000000004180. Epub 2025 Oct 23.

Drugs

Indications