Treatment of Malignant Tumors With Antigen Peptide-specific DC-CTL Cells and Decitabine

Summary

Tumor-specific antigens can be induced by demethylation drugs. Antigen-targeting DC-CTL cells supposed to eliminate cancer cells efficiently and specifically. In this study investigators co-culture DCs cells with peptides derived from tumor specific antigen to generate antigen-specific DC-CTLs (Ag-CTL). Following treatment with demethylation drugs, Ag-CTL will be used to eliminate tumor cells. This study aims to evaluate the effectiveness and safety of Ag-CTL combined with demethylation drugs.

Timeline

Start

2020-10-30

Primary completion

2023-07-28

Completion

2023-07-28

Drugs

Indications