Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients

Summary

This study aims to determine the efficacy of montelukast in reducing the incidence of dengue warning signs in adult dengue patients.

Timeline

Start

2021-01-15

Primary completion

2023-06-17

Completion

2023-06-17

Outcome

Missed primary endpoint

paper There was no difference between the two groups (HR 1.36; 95%CI 0.94-1.96, P = 0.105). PMID 38306389 ↗

paper CONCLUSION: Oral montelukast does not reduce the incidence of warning signs among patients with dengue. PMID 38306389 ↗

Publications

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• Nitinai N, Nasomsong W, Chuerboonchai W, Tweekittikul A, Khingmontri V, Panuvatvanich B, Bangchuad T, Pongpraijaroen M, Roongfa-Ngarm T, Vasikasin V. Effect of montelukast in preventing dengue with warning signs among patients with dengue: A multicenter, randomized, double-blind, placebo-controlled trial. PLoS Negl Trop Dis. 2024 Feb 2;18(2):e0011927. doi: 10.1371/journal.pntd.0011927. eCollection 2024 Feb.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Montelukast	Other / unclassified	10 mg	Oral

Indications