Registry for Migraine - Structural and Functional MRI Before and After Erenumab Treatment

Summary

This study aims to investigate structural and functional cerebral changes using magnetic resonance imaging before and after treatment with erenumab in patients with migraine.

Timeline

Start

2020-10-22

Primary completion

2025-07-22

Completion

2025-07-22

Publications

• Chaudhry BA, Christensen RH, Ashina H, Al-Khazali HM, Amin TM, Ashina M, Amin FM. No differences in subcortical volume between people with and without migraine: A REFORM study. Headache. 2026 Feb;66(2):494-501. doi: 10.1111/head.70001. Epub 2025 Nov 14.
• Gollion C, Ashina H, Hackert Christensen R, Al-Khazali HM, Tolnai D, Ashina M, Mohammad Amin F. Intact white matter in adults with migraine: A REFORM MRI study. Cephalalgia. 2025 May;45(5):3331024251339423. doi: 10.1177/03331024251339423. Epub 2025 May 30.
• Karlsson WK, Christensen RH, Al-Khazali HM, Kallemose T, Jawad BN, Andersen O, Ashina M, Ashina H. Plasma SuPAR and therapeutic response to erenumab in migraine: a REFORM study. J Headache Pain. 2025 Apr 24;26(1):86. doi: 10.1186/s10194-025-02037-9.
• Christensen RH, Ashina H, Al-Khazali HM, Zhang Y, Tolnai D, Poulsen AH, Cagol A, Hadjikhani N, Granziera C, Amin FM, Ashina M. Differences in Cortical Morphology in People With and Without Migraine: A Registry for Migraine (REFORM) MRI Study. Neurology. 2024 May;102(9):e209305. doi: 10.1212/WNL.0000000000209305. Epub 2024 Apr 17.
• Karlsson WK, Ashina H, Cullum CK, Christensen RH, Al-Khazali HM, Amin FM, Ashina M; REFORM Investigators. The Registry for Migraine (REFORM) study: methodology, demographics, and baseline clinical characteristics. J Headache Pain. 2023 Jun 12;24(1):70. doi: 10.1186/s10194-023-01604-2.

Drugs

Indications