Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema

Phase 2 Terminated 2 enrolled Washington University School of Medicine

RandomizedParallel-groupSingle-blindTreatment

Summary

Angiotensin Converting Enzyme (ACE) inhibitors are among the most important and widely prescribed drugs. They reduce the morbidity and mortality associated with high blood pressure, heart disease, and kidney disease. Unfortunately, their use carries the risk of causing life-threatening airway swelling in some patients. There is currently no treatment for this condition. A novel treatment approach that may reduce or completely reverse the swelling will be tested.

Timeline

Start: 2020-12-22
Primary completion: 2023-01-31
Completion: 2023-01-31

Outcome

Outcome not reported

Stopped (Business): “End of funding period”

Publications

Background Chen SX, Hermelin D, Weintraub SJ. Possible donor-dependent differences in efficacy of fresh frozen plasma for treatment of ACE inhibitor-induced angioedema. J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):2087-2088. doi: 10.1016/j.jaip.2019.02.027. Epub 2019 Mar 2. No abstract available.

Drugs