Plasma Resuscitation Without Lung Injury

Summary

The treatment of patients with major burns requires resuscitation with massive amounts of fluid, typically a type of salt water that is given by vein. This frequently results in injury to vital organs, especially the lungs and kidneys, and even in death. In this study, the investigators propose to use plasma, a specially prepared blood product made from the liquid part of blood, that has undergone special treatment to reduce the risk of disease transmission. The aims include 1) reduce the amount of fluid given during the first 24 hours after a burn 2) reduce the incidence of lung injury and other complications related to the administration of funds and 3) determine if the blood product has any effect on inflammation. An overall decrease the amount of fluids that burn patients receive should decrease the potential for lung injury, decrease days in the hospital, and improve survival.

Timeline

Start

2022-08-17

Primary completion

2024-06-29

Completion

2024-09-29

Outcome

Outcome not reported

Stopped (Enrollment): “Enrollment targets were unable to be reached due to difficulty in locating and contacting the Legally Authorized Representative (LAR). Even with prolonged enrollment timeframe, the study was unable to obtain consent from the LAR.”

Drugs

Indications

No indication recorded.