Treatment of Early Hypertension Among Persons Living With HIV in Haiti

Summary

The investigators are conducting an unblinded pilot randomized control trial of 250 persons living with HIV (PLWH), aged 18-65 years, who receive antiretroviral therapy care at Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), are virally suppressed, and have pre-hypertension (systolic blood pressure (SBP) 120-139 or diastolic blood pressure (DBP) 80-89 mmHg) to be randomized to early hypertension (HTN) treatment versus standard of care (SOC). Participants will be recruited from GHESKIO's HIV clinic. Eligible individuals will complete informed consent and be randomized to early HTN treatment vs. SOC. Participants in early HTN treatment will initiate amlodipine immediately versus those in SOC will initiate amlodipine only if they meet the HTN threshold (SBP ≥140 or DBP ≥90 mmHg) during the study period. All participants will be followed for 12 months.

Timeline

Start

2021-02-26

Primary completion

2023-06-30

Completion

2023-12-30

Publications

• Yan LD, Rouzier V, Sufra R, Sauveur RS, Guiteau C, Lee MH, Ogyu A, Mourra N, Oparil S, Theard M, Brisma JP, Alfred JP, Deschamps MD, Pape JW, McNairy ML. Treatment of prehypertension among adults with HIV. AIDS. 2025 Mar 1;39(3):261-269. doi: 10.1097/QAD.0000000000004065. Epub 2024 Nov 13.
• Yan LD, Rouzier V, Dade E, Guiteau C, Pierre JL, St-Preux S, Metz M, Oparil S, Pape JW, McNairy M. Treatment of early hypertension among persons living with HIV in Haiti: Protocol for a randomized controlled trial. PLoS One. 2021 Aug 5;16(8):e0254740. doi: 10.1371/journal.pone.0254740. eCollection 2021.

Drugs

Indications