drugset
drugset / Trial / NCT04695509

Sedation and Neuromediators Concentration

NCT04695509 ↗

Completed 24 enrolled I.M. Sechenov First Moscow State Medical University
Non-randomizedParallel-groupSingle-blindBasic science

Summary

Propofol (Propofol Kabi, Registration number from the State Register of Medicines - 000875) is a widely used intravenous anesthetic. It is well known about different effects of propofol infusion, including euphoria, psycholalia, disinhibition, talkativeness, satisfaction etc. However, the basic mechanisms of such effects remain unknown. We suppose that propofol sedation with various levels of sedation (from light to deep) leads to neuromediators changes. We examine dopamine, noradrenaline, acetylcholine, GABA and serotonin in peripheral venous blood before, during and after propofol sedation. Therefore, we suppose drugs for sedation, in particular, propofol will affect neuromediators concentration.

Timeline

Start
2020-10-05
Primary completion
2021-01-15
Completion
2021-04-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Propofol Small molecule — Intravenous

Indications

No indication recorded.