Exercise and PRP vs Exercise Alone in Patients With Knee Osteoarthritis

Summary

This study is a prospective randomized controlled study of different treatments for knee osteoarthritis and aims to investigate the efficacy of exercise combined platelet rich plasma (PRP) injection versus only exercise or only PRP treatments.

Timeline

Start

2021-01-31

Primary completion

2022-01-07

Completion

2022-02-10

Outcome

Missed primary endpoint

paper PRP did not improve pain at 24 weeks of follow-up in patients with mild-to-moderate knee osteoarthritis compared with exercise alone. PMID 38323999 ↗

paper mean difference between PRP + exercise group and exercise group -0.5 [95% confidence interval -1.2 to 0.4]; p = 0.69 PMID 38323999 ↗

Publications

• Results Karaborklu Argut S, Celik D, Ergin ON, Kilicoglu OI. Does the Combination of Platelet-rich Plasma and Supervised Exercise Yield Better Pain Relief and Enhanced Function in Knee Osteoarthritis? A Randomized Controlled Trial. Clin Orthop Relat Res. 2024 Jun 1;482(6):1051-1061. doi: 10.1097/CORR.0000000000002993. Epub 2024 Feb 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Platelet Rich Plasma	Other / unclassified	—	Other

Indications