Arthroscopic Rotator Cuff Repair Augmented With Platelet Rich Plasma

Completed 103 enrolled Hospital Italiano de Buenos Aires

RandomizedParallel-groupSingle-blindTreatment

Summary

Purpose: To assess whether the use of platelet-rich plasma used as an adjuvant to arthroscopic rotator cuff repairs modify the rate of re-tears (measured by MRI) compared to a control group that only underwent the isolated arthroscopic repair. Hypothesis: Platelet rich plasma used as an adjuvant to arthroscopic rotator cuff repairs decrease the rate of retears.

Timeline

Start: 2021-01-03
Primary completion: 2022-09-01
Completion: 2022-09-01

Outcome

Met primary endpoint

paper The retear rate in the PRP group was 15.2% (7/46 [95% CI, 6%-28%]), which was lower than that in the control group PMID 38587033 ↗

paper a 5-mL dose of LP-PRP injected at the tendon-bone interface significantly reduced the retear rate. PMID 38587033 ↗

Publications

Rossi LA, Gorodischer TD, Camino P, Brandariz RN, Tanoira I, Piuzzi NS, Ranalletta M. Leukocyte-Poor Platelet-Rich Plasma as an Adjuvant to Arthroscopic Rotator Cuff Repair Reduces the Retear Rate But Does Not Improve Functional Outcomes: A Double-Blind Randomized Controlled Trial. Am J Sports Med. 2024 May;52(6):1403-1410. doi: 10.1177/03635465241239062. Epub 2024 Apr 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Platelet Rich Plasma	Other / unclassified	10 ml	Other