Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study

Phase 2 Active not recruiting 10 enrolled Anders Fink-Jensen, MD, DMSci The Neurobiology Research Unit at Copenhagen University Hospital Rigshospitalet · collab

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this project is to assess the feasibility and safety of administering a single dose of psilocybin to patients diagnosed with alcohol use disorder (AUD). In addition the investigators will establish the pharmacokinetic properties of the active metabolite psilocin. This is the first step in a research project that has the overall aim to evaluate the efficacy of a single administration of psilocybin as an intervention for treatment of AUD.

Timeline

Start: 2023-02-09
Primary completion: 2024-07-21
Completion: 2024-07-21

Publications

Jensen ME, Stenbaek DS, Messell CD, Poulsen ED, Varga TV, Fisher PM, Nielsen MKK, Johansen SS, Volkow ND, Knudsen GM, Fink-Jensen A. Single-dose psilocybin therapy for alcohol use disorder: Pharmacokinetics, feasibility, safety and efficacy in an open-label study. J Psychopharmacol. 2025 May;39(5):463-473. doi: 10.1177/02698811251319457. Epub 2025 Feb 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Psilocybin	Other / unclassified	25 mg	Oral

Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study

Summary

Timeline

Publications

Drugs

Indications