Evaluation the Safety and Tolerance of GP681 Tablets in Healthy Subjects

Summary

Influenza (influenza for short) is an acute respiratory infectious disease caused by influenza virus. The symptoms of the disease range from mild, moderate to severe, and severe cases require hospitalization and may die. According to estimates by the US Centers for Disease Control and Prevention in 2018, influenza causes approximately 290,000 to 640,000 deaths worldwide each year. Therefore, the prevention and treatment of influenza has become a serious public health problem.

Timeline

Start

2020-08-27

Primary completion

2020-12-15

Completion

2020-12-15

Publications

• Wu Q, Lv L, Yan S, Wang Y, Chen Q, Xu W, Liu Y, Wang W, Jia J, Yu C, Chen J, Liu Y. A first-in-human phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel anti-influenza agent suraxavir marboxil in healthy Chinese subjects. Antimicrob Agents Chemother. 2025 Nov 5;69(11):e0068525. doi: 10.1128/aac.00685-25. Epub 2025 Sep 30.

Drugs

Indications