NCT04761159: Ketamin Plus Propofol for Anesthesia Induction

Summary

ASA I-II 112 pediatric patients will recruit who underwent adenoidectomy-tonsillectomy surgery. Propofol 1 mg/kg + ketamin1 mg/kg (1/1 ratio) for group I; propofol 1,5 mg/kg + ketamin 0,75 mg/kg (2/1 ratio) for group II; propofol 2 mg/kg +ketamin 0,66 mg/kg (3/1 ratio) for group III; propofol 3 mg/kg will perform for anesthesia induction. General anesthesia will maintenance with sevoflurane 1-2% and O2/N2O mixture. Morphine 0.1mg/kg IV will be apply for postoperative analgesia at 10 min of anesthesia. Extubation time, length of stay in PACU, Watcha score, FLACC score will record. Than all data will statistically analyse.

Timeline

Start: 2021-02-15
Primary completion: 2022-12-15
Completion: 2022-12-15

Publications

Biricik E, Karacaer F, Tunay DL, Ilginel M, Kucukbingoz C. The Effect of Different Propofol-Ketamine Combinations on Emergence Delirium in Children Undergoing Adenoidectomy and Tonsillectomy Surgery. J Perianesth Nurs. 2024 Dec;39(6):1012-1018. doi: 10.1016/j.jopan.2024.01.019. Epub 2024 Jun 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ketamine	Small molecule	0.66 mg/kg	—
Comparator	Ketamine	Small molecule	0.75 mg/kg	—
Comparator	Ketamine	Small molecule	1 mg/kg	—

Indications

No indication recorded.